Convergence of TMS Sites and Lesion Locations Associated With Nicotine Addiction Improvement on a Common Brain Circuit

The authors aimed to determine whether transcranial magnetic stimulation (TMS) sites that are more connected to a lesion-derived brain circuit associated with nicotine addiction remission correlate with greater reductions in withdrawal symptoms among individuals with tobacco use disorder. Their findings indicate a significant association between TMS site connectivity to this circuit and improvements in withdrawal symptoms, suggesting that targeting this common brain circuit may enhance the effectiveness of TMS interventions for nicotine addiction.