May 5, 2026 · Menopause (New York, N.Y.) · DOI: 10.1097/GME.0000000000002802

Biological markers of aging across the menopause transition: current evidence

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This review investigates the role of biological markers of aging in women during the menopause transition, aiming to understand how hormonal changes influence individual health variability and biological aging. The authors synthesize current evidence on various biomarkers, such as epigenetic clocks and telomere length, and their association with menopause-related factors, including vasomotor symptoms and hormone therapy. They highlight the need for further research to establish clinically meaningful thresholds for these biomarkers and to enhance precision health strategies for women.

Regina Castaneda, Erin R Uddenberg, Maria D Hurtado Andrade, Jesse L Meek, Kaylin N Frankhouser, Stephanie S Faubion, Eduardo N Chini, Nathan K LeBrasseur, Pamila K Brar, Chrisandra L Shufelt

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