Maternal Hyperglycemia and Adult Offspring Overweight and Obesity: Is Birthweight a Mediator?
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The authors aimed to investigate whether birthweight mediates the relationship between maternal hyperglycemia during pregnancy and the risk of overweight and obesity in adult offspring of women with insulin-dependent diabetes mellitus (IDDM). Their findings indicate that while higher birthweight is associated with increased adult obesity risk, it does not mediate the effects of maternal glycemic patterns on offspring weight outcomes. This underscores the need for further exploration of how trimester-specific glycemic control influences long-term metabolic risks in offspring.
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