December 26, 2001 · Early pregnancy

New placental factors: Between implantation and inflammatory reaction

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The authors investigate the roles of inducible nitric oxide synthase (iNOS), adrenomedullin (AM), fatty acid synthase (FAS), and S-100 protein in trophoblast invasion and their relationship to inflammatory reactions during early pregnancy. They aim to understand how these factors differ in expression between spontaneous abortion (SA) and voluntary pregnancy termination (VPT), suggesting that variations in these placental factors may reflect functional modifications in placental tissues. Their findings indicate that AM and nitric oxide levels are higher in VPT compared to SA, highlighting a potential link between implantation processes and inflammatory responses.

G Urban, E Marinoni, R Di Iorio, C Lucchini, P Alo, U Di Tondo

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