Abnormal pattern of integrin expression at the implantation window in endometrium from fertile women treated with clomiphene citrate and users of intrauterine device
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The authors aimed to investigate the quantitative expression of endometrial integrins during the implantation window in fertile women treated with clomiphene citrate (CC) and users of intrauterine devices (IUD), compared to fertile controls. They found that CC treatment led to abnormal integrin expression patterns and a high incidence of out-of-phase endometrium, while IUD use altered integrin expression through a different mechanism. Overall, both treatments impacted endometrial receptivity by modifying the expression of specific integrins in epithelial and stromal cells.
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