The association between sporadic somatic parental aneuploidy and chromosomally abnormal placentae in habitual abortions
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The authors aimed to investigate the relationship between parental somatic aneuploidy and the karyotype of abortuses in couples experiencing recurrent miscarriages. They found that a significant proportion of parents whose abortuses had chromosomal abnormalities also exhibited high levels of aneuploid cells in their peripheral lymphocytes, suggesting that mitotic instability in these cells may predispose couples to chromosomal abnormalities in embryos and subsequent miscarriages.
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