The Frame of Survival for Sepsis: A Practical Systems Framework for Time-Sensitive Critical Illness in Low-Resource Settings

The authors aim to develop a practical framework, the "Sepsis Frame of Survival," to improve sepsis management in low-resource settings (LRS), addressing the high mortality rates associated with this time-sensitive condition. By conducting a targeted scoping review and engaging a multidisciplinary task force, they identify actionable strategies and prioritize feasible interventions that can be integrated into existing emergency and critical care systems. The framework emphasizes immediate, high-impact actions while recognizing the need for local evidence to inform ongoing quality improvement efforts.