March 20, 2026 · Foot & ankle international · DOI: 10.1177/10711007261424900

Impact of Non-Tobacco Nicotine Use on Outcomes Following Total Ankle Arthroplasty

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The authors investigate the impact of non-tobacco nicotine (NTN) use on surgical outcomes following total ankle arthroplasty (TAA), given the established adverse effects of tobacco-derived nicotine. Their retrospective cohort study reveals that NTN users experience significantly higher rates of surgical site complications within the first year post-surgery, while no significant differences were noted for implant-related outcomes or healthcare use. The findings suggest that incorporating NTN use into preoperative assessments may enhance risk stratification and patient counseling.

Pranav Sivaram, Prajwal Guruprasad, Conor N O'Neill, Cesar de Cesar Netto, Samuel B Adams, Albert T Anastasio

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