March 19, 2026 · Obstetrics and gynecology · DOI: 10.1097/AOG.0000000000006241

Effect of Medical Therapies for Endometriosis on Bone Health: A Systematic Review and Meta-analysis

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The authors aimed to evaluate the impact of various medical therapies for endometriosis on bone mineral density (BMD). Their systematic review and meta-analysis revealed that hormonal treatments, particularly GnRH agonists and dienogest, are associated with a significant decrease in BMD after 12 months of use, although the clinical implications of these findings remain uncertain. The study underscores the need for expert consensus on managing bone health in patients undergoing long-term hormonal therapy for endometriosis.

Jade Desilets, Rosa Lakabi, Alisha Olsthoorn, John Matelski, Chris Walsh, Ally Murji, Elizabeth Miazga

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