January 16, 2026 · American family physician

Resistant Hypertension in Adults: Evaluation and Treatment

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This article addresses the evaluation and management of resistant hypertension in adults, defined as blood pressure that remains above target despite optimal treatment with three antihypertensive medications, including a diuretic. The authors emphasize the importance of thorough assessment for comorbidities, medication adherence, and accurate blood pressure measurement before diagnosing resistant hypertension, and they propose a structured management approach that includes lifestyle modifications and a specific medication regimen. Additionally, they discuss the role of advanced treatment options for patients who do not respond adequately to standard therapies.

Sean P Haley, Scott Bragg, Leah Stem

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