Recipient Endothelial IRF1 mediates IFNγ-driven tissue tolerance in mouse models of acute Graft-versus-Host Disease

The authors investigate how recipient endothelial cells (ECs) influence the pathology of acute graft-versus-host disease (GVHD) following allogeneic hematopoietic cell transplantation (allo-HCT), specifically focusing on the role of interferon-γ (IFNγ) and the transcription factor IRF1. Their findings reveal that IFNγ-IRF1 signaling in lymphatic ECs is crucial for mediating tissue tolerance and regulating donor T cell responses, suggesting that a balanced activation of this pathway is essential for improving post-transplant outcomes and reducing GVHD severity.