August 6, 2026 · Blood · DOI: 10.1182/blood.2025031311

How I treat autoimmune neutropenia in adults

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The authors aim to address the management of autoimmune neutropenia (AiN) in adults, a rare condition that is often chronic and typically asymptomatic despite low neutrophil counts. They highlight the challenges in treatment due to the variable clinical presentation and the unclear mechanisms behind neutrophil destruction, suggesting that observation and supportive care are usually preferred. The paper discusses potential treatment strategies, including boosting neutrophil production and targeting immune-mediated destruction, while emphasizing the need for collaborative efforts to improve treatment approaches for this condition.

Rebecca K Leaf, David B Sykes

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