August 3, 2026 · Annals of internal medicine · DOI: 10.7326/ANNALS-26-02636-JC

In alcohol use disorder and comorbid obesity, weekly semaglutide reduced heavy drinking days at 26 wk

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The authors investigate whether weekly administration of semaglutide can reduce heavy drinking days in individuals with alcohol use disorder and comorbid obesity. Their findings indicate that semaglutide treatment led to a significant reduction in heavy drinking days over a 26-week period. This suggests a potential therapeutic role for semaglutide in managing alcohol use disorder in this patient population.

Mat Rose, ACP Journal Club Editorial Team at McMaster University

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