August 3, 2026 · Annals of internal medicine · DOI: 10.7326/ANNALS-26-02578-JC

In noncardioembolic ischemic stroke or high-risk TIA, asundexian reduced ischemic stroke and did not increase major bleeding

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The authors investigate whether asundexian can reduce the incidence of ischemic strokes in patients with noncardioembolic ischemic stroke or high-risk transient ischemic attacks (TIAs) without increasing the risk of major bleeding. The findings suggest that asundexian effectively lowers the risk of ischemic stroke while maintaining a safety profile regarding major bleeding events.

Michael D Hill, ACP Journal Club Editorial Team at McMaster University

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