Clinical Implications of Resting Metabolic Rate in Heart Failure with Preserved Ejection Fraction

The authors investigate the role of resting metabolic rate (RMR) in patients with heart failure with preserved ejection fraction (HFpEF) and its clinical implications. They categorize patients based on their RMR and find that those with higher-than-expected RMR exhibit certain hemodynamic adaptations at rest but show impaired cardiovascular reserve during exercise, leading to a higher risk of adverse outcomes. The study highlights the need for further research to understand how RMR influences the pathophysiology of HFpEF and its potential as a therapeutic target.