June 18, 2026 · Obstetrics and gynecology · DOI: 10.1097/AOG.0000000000006356

Oral and Vaginal Probiotics and Pregnancy Outcomes in Women With Infertility: A Systematic Review and Meta-analysis

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The authors aimed to investigate the impact of oral and vaginal probiotic use on pregnancy outcomes in women experiencing infertility. Their systematic review and meta-analysis of 16 studies revealed that oral probiotics were linked to increased biochemical and clinical pregnancy rates, as well as higher live-birth rates, while vaginal probiotics were associated with a reduced risk of miscarriage. However, the overall quality of the evidence was deemed low to very low.

Maedeh Moradi, Jessica A Grieger, Yilin Tong, Leonie K Heilbronn

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