Ketamine versus propofol for sedation in acute psychiatric emergencies during aeromedical retrieval: a randomized clinical trial

This study aimed to determine the safety and efficacy of ketamine versus propofol for sedation in acutely agitated patients during aeromedical retrieval. The results indicated that ketamine was associated with fewer adverse events compared to propofol, although clinicians expressed a preference for propofol despite both medications achieving similar sedation efficacy. The trial highlights the need for optimal sedation strategies in the context of limited mental health resources in regional Australian communities.