A Semi-automated Image Analysis Determination of Regional Differences in Corneal Endothelial Cell Densities in Fuchs Endothelial Corneal Dystrophy

This study aims to quantify regional differences in corneal endothelial cell density (ECD) in patients with Fuchs endothelial corneal dystrophy (FECD) across various disease grades. The authors found that central ECD is significantly lower than peripheral regions in advanced FECD, with the most severe reductions observed in central and inferotemporal regions, highlighting the progressive nature of endothelial cell loss in this condition. Additionally, the study indicates that sex and diabetes do not significantly influence ECD outcomes.