Multicenter Insights into Pediatric Extreme Leukocytosis: A 5-Year Retrospective Study

This study aimed to compare the clinical outcomes of pediatric patients with extreme leukocytosis (EL) to those with moderate leukocytosis (ML) in an emergency department setting. The findings revealed that EL is more commonly associated with infections, evidenced by younger age, higher inflammatory markers, and a higher rate of positive cultures, while malignancy was rare. The results underscore the necessity for targeted monitoring of patients with extreme leukocytosis due to its infection-related nature.