June 11, 2026 · Journal of the American Academy of Dermatology · DOI: 10.1016/j.jaad.2026.06.029

Effectiveness and safety of hematoporphyrin monomethyl ether-mediated photodynamic therapy versus pulsed dye laser for port-wine stain: a retrospective study

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The authors aimed to compare the effectiveness and safety of hematoporphyrin monomethyl ether-mediated photodynamic therapy (HMME-PDT) versus pulsed dye laser (PDL) for treating port-wine stains on the face and neck. Their retrospective study found that HMME-PDT resulted in a higher rate of excellent improvement (41.5% vs. 29.2%) compared to PDL, although it was associated with increased risks of hyperpigmentation and scarring.

Xiaoxue Li, Lian Liu, Ping Diao, Lidan Zhang, Ting Zhang, Yanmei Li, Chenglong Han, Haotian Chen, Danfeng Wei, Haoda Yu, Qingfeng Liu, Xian Jiang

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