Plasma Lidocaine Concentrations During Intravenous Lidocaine Infusion Therapy in the Pediatric Population-A Scoping Review

The authors conducted a scoping review to assess the pharmacokinetic data of intravenous lidocaine therapy (IVLT) in pediatric patients aged 1-18 years, as the dosing and plasma concentration ranges are not well defined for this population. They found that existing studies report plasma concentrations of lidocaine that are detectable and generally below presumed toxic levels, with only one adverse event noted. The authors emphasize the need for larger, multicenter studies to establish optimal dosing and safety protocols for IVLT in children.