June 8, 2026 · Journal of addiction medicine · DOI: 10.1097/ADM.0000000000001732

Case Report: Oral-Nasal Damage in a Person Using Fentanyl and Xylazine

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The authors aim to document the oral-nasal damage resulting from the intranasal use of fentanyl and xylazine, substances that have become increasingly common in illicit drug use. They present a case of a 39-year-old woman who experienced severe nasal and palate damage, highlighting the need for clinicians to recognize and address the potential complications associated with these drugs. This case underscores the importance of appropriate referrals for treatment of substance use disorders and related physical damage.

Julie Kmiec, Garret Choby

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