Thrombocytosis: Rapid Evidence Review

This review addresses the causes, diagnosis, and management of thrombocytosis, particularly focusing on distinguishing between secondary causes and primary conditions like essential thrombocythemia. The authors emphasize the importance of confirming persistent thrombocytosis through repeated blood tests and genetic testing, as well as the need for risk stratification to guide treatment decisions. They conclude that while hydroxyurea is the primary treatment for essential thrombocythemia, current therapies do not improve survival or prevent disease progression.