May 7, 2026 · Obstetrics and gynecology · DOI: 10.1097/AOG.0000000000006314

History of Treated Syphilis Before Pregnancy and Risk of Congenital Syphilis

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The authors aimed to evaluate the risk of congenital syphilis in neonates born to mothers with a history of adequately treated syphilis before pregnancy compared to those without such a history. Their study found that mothers with a prior history of treated syphilis had significantly higher rates of congenital syphilis and maternal reinfection during pregnancy, suggesting that previous treatment does not confer the expected protective effects and highlighting the need for enhanced monitoring in this population.

J Drew Toppin, Shannon McCloskey, Talia Suner, Brian James, Meenakshi Mishra, Mariella Gastanduy, Joseph R Biggio, Frank B Williams

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