April 26, 2026 · Prenatal diagnosis · DOI: 10.1002/pd.70146

Foetal Persistent Left Superior Vena Cava-Not Always a Benign Finding?

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The authors aimed to assess the prevalence of extra-cardiac anomalies and genetic variations in foetuses diagnosed with persistent left superior vena cava (PLSVC) alongside a structurally normal heart. Their findings revealed that 25% of the cases had associated structural anomalies and 9.5% had genetic abnormalities, suggesting that PLSVC may not be a benign finding and highlighting the need for thorough anatomical assessments and potential genetic testing in affected foetuses.

Nadezhda Dzhelepova, Caroline B Jones, Sophia Khan

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