Intranasal Versus Intramuscular Midazolam in Pediatric Seizure Control: A Systematic Review and Meta-Analysis
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The authors aimed to determine whether intranasal (IN) or intramuscular (IM) administration of midazolam is more effective for rapid seizure control in pediatric patients, particularly in prehospital settings where intravenous access is not available. Their meta-analysis of five studies involving 3,933 patients found that IM midazolam resulted in quicker seizure termination and a lower need for rescue therapy compared to IN midazolam. Consequently, IM midazolam is suggested as a preferable first-line treatment for acute seizures in these scenarios.
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