April 17, 2026 · Urogynecology (Philadelphia, Pa.) · DOI: 10.1097/SPV.0000000000001829

The Role of EMMPRIN Levels in Uterine Ligaments in Pelvic Organ Prolapse

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The authors investigate the role of extracellular matrix metalloproteinase inducer (EMMPRIN) levels in uterine ligaments as a potential factor in the etiopathogenesis of pelvic organ prolapse (POP). They found that EMMPRIN levels were significantly lower in women with POP compared to those without, suggesting that EMMPRIN deficiency may contribute to the development of POP. The study highlights the need for further multicenter research with larger sample sizes to confirm these findings.

Ayşe Ceren Yildiz, Zelal Aydin, Kübra Keskin Toptaş, Fatma Sağlam Karaoğlan, Hande Soyer Somunsu, Berna Aslan Çeti̇n, Kubra Bozali, Eray Metin GuleR

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