May 23, 2024 · Frontline gastroenterology · DOI: 10.1136/flgastro-2023-102405

What is the clinical significance of low serum amylase? Systematic review of the conditions associated with low serum amylase

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The authors aimed to investigate the clinical significance of low serum amylase levels and the conditions associated with it, as previous research has primarily focused on elevated levels. Through a systematic review of 19 studies involving over 15,000 patients, they identified conditions such as diabetes mellitus, metabolic syndrome, and chronic pancreatitis linked to low serum amylase. The findings suggest that low serum amylase may serve as a valuable adjunct in diagnosing chronic pancreatitis and assessing pancreatic exocrine insufficiency.

Mustafa Jalal, Sebastine A Gbadegesin, Nadeem Tehami, Kei Nakajima

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