Fetal Fentanyl Syndrome: An Opportunity to Quantify the Risk in Prospective Cohorts of Patients With Substance Use Disorder

The authors investigate the emerging concern of "fetal fentanyl syndrome" (FFS) due to increased fentanyl exposure among pregnant women and its potential risks to fetal development. They highlight the limitations of recent studies that attempt to quantify the risk of FFS, noting issues such as selective case ascertainment and confounding factors, and emphasize the need for further research to clarify the relationship between prenatal fentanyl exposure and specific congenital anomalies.