Muscle & nerve
Muscle & nerve
Audio Summaries
Every issue of Muscle & nerve moves the field forward, but reading every paper cover-to-cover isn't realistic. OSLR turns each article into a 3-minute audio summary so you can stay current while you commute, round, or work out.
Recent summaries
The latest articles summarized from Muscle & nerve.
Frataxin Expression in Sensory Neurons Is Required for Muscle Spindle Function and Proprioception
Jun 10, 2026
This study investigates the role of frataxin expression in sensory neurons on muscle spindle function and proprioception in a murine model of Friedreich's Ataxia. The authors found that while early-stage mutant mice showed no significant deficits, those at a later stage exhibited severe locomotor ataxia and impaired proprioceptive sensitivity, indicating that frataxin is essential for maintaining normal muscle spindle function and proprioceptive acuity. These findings suggest that motor coordination deficits in Friedreich's Ataxia may stem from dysfunctional muscle spindles.
Two Patients With Juvenile-Onset, Rapidly Progressive Amyotrophic Lateral Sclerosis Associated With an SOD1 Variant (p.Asp125Gly) With Incomplete Penetrance
Jun 10, 2026
This study investigates the clinical and genetic characteristics of two adolescents with juvenile-onset, rapidly progressive amyotrophic lateral sclerosis (ALS) associated with the SOD1 variant p.Asp125Gly. The authors aim to expand the understanding of SOD1-ALS phenotypes, particularly in younger patients, and highlight the variant's incomplete penetrance as it was inherited from asymptomatic fathers. The findings underscore the importance of recognizing juvenile SOD1-ALS in the context of emerging targeted therapies.
The Flail Limb Syndrome
Jun 9, 2026
The authors aim to compile and clarify the clinical and electrophysiologic features of flail limb syndrome (FLS), a rare lower motor neuron disorder distinct from classic amyotrophic lateral sclerosis (ALS). They highlight the syndrome's characteristics, including its male predominance, slower progression to respiratory failure, and the variability of upper motor neuron signs, while noting the lower frequency of associated genetic mutations compared to classic ALS. The study emphasizes the importance of a two-year period of regional stability for accurate diagnosis and prognosis.