June 11, 2026 · Annals of surgical oncology · DOI: 10.1245/s10434-026-19931-4

Predicting Failure of Active Surveillance in Desmoid-Type Fibromatosis Using Radiomics: An International Multi-center Cohort Study

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The authors aimed to determine whether radiomics can effectively predict the failure of active surveillance (AS) in patients with desmoid-type fibromatosis (DTF). In a multicenter study involving 200 patients, they developed prediction models based on MRI features, achieving varying levels of accuracy across different cohorts. The findings suggest that while the radiomics approach shows promise, further improvements are needed to enhance model performance and patient selection for AS.

Stefanie N Hakkesteegt, Douwe J Spaanderman, Chiara Colombo, Anne-Rose W Schut, Andrea Vanzulli, Francesco Barretta, C Morosi, Marco Fiore, Peter Ferguson, Harini Suraweera, Anthony M Griffin, Lawrence M White, Joel Shapiro, Danchen Ge, Dirk J Grünhagen, Geert J L H van Leenders, David Hanff, Jacob J Visser, Wiro J Niessen, Stefan Klein, Dutch Grafiti Research Group, Rebecca A Gladdy, Alessandro Gronchi, Cornelis Verhoef, Martijn P A Starmans

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