Cryoprecipitate utilization in the neonatal intensive care unit: a single-center review

The authors aimed to evaluate the indications, dosing, and incidence of multi-donor exposure associated with cryoprecipitate transfusions in neonates within a single neonatal intensive care unit. Their retrospective review of 104 transfusions revealed significant variability in practices, with a notable 30% of transfusions likely leading to multi-donor exposure, yet no significant improvement in post-transfusion fibrinogen levels was observed with increased dosing. This highlights the need for standardized protocols to optimize transfusion practices in this vulnerable population.