Higher versus Routine Intraoperative Blood Pressure Targets in Noncardiac Surgery: A Systematic Review and Meta-analysis with Trial Sequential Analysis of Randomized Trials

The authors aimed to determine whether targeting higher intraoperative blood pressure values during noncardiac surgery improves clinical outcomes compared to routine blood pressure management. Their systematic review and meta-analysis of 15 randomized trials involving over 15,000 patients found no significant benefits in major postoperative outcomes, such as acute kidney injury or mortality, although there was a potential reduction in postoperative delirium that requires further investigation. Overall, the findings suggest that higher blood pressure targets do not confer substantial advantages in this surgical context.