The SPRR2A-CSTA Axis Drives IL-17A-Induced Squamous Metaplasia and Steroid Resistance in Allergic Rhinitis
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The authors investigate the molecular mechanisms driving squamous metaplasia (SM) and glucocorticoid resistance in refractory allergic rhinitis (AR), focusing on the role of the SPRR2A-CSTA axis. Their findings reveal that SPRR2A is a key marker associated with SM, promoting keratinization and steroid resistance through the action of CSTA. This study identifies the SPRR2A-CSTA axis as a potential therapeutic target and biomarker for managing refractory AR.
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