An integrated systemic approach to chronic primary pain from epigenome to brain: a narrative review

The authors aim to establish an integrated systemic approach to understanding chronic primary pain, which is recognized as a complex disease involving multiple physiological dysfunctions, including epigenetic modifications and neuroinflammation. By connecting insights from various scientific disciplines, they seek to create a holistic framework that links these dysfunctions to clinical features such as sensory hypersensitivity and psychological issues, ultimately enhancing therapeutic strategies and guiding future research.