Non-antibiotic interventions to prevent recurrent urinary tract infections in women: overview of systematic reviews of randomised controlled trials

The authors aimed to evaluate the effectiveness of non-antibiotic interventions for preventing recurrent urinary tract infections (rUTIs) in women through an overview of systematic reviews of randomized controlled trials. They found that while cranberry, methenamine hippurate, and vaginal estrogen (in postmenopausal women) are supported by existing evidence, many other interventions, such as probiotics and D-mannose, require further research to establish their efficacy. Additionally, questions remain regarding optimal dosing, treatment adherence, and acceptability for various interventions.